Nucleotide repeat expansion-associated polypeptides and uses...

Details Nucleotide repeat expansion-associated polypeptides and uses... Nucleotide repeat expansion-associated polypeptides and uses...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2757354

Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats include at least six contiguous amino acids of a tetra- or penta-amino acid repeat block.

Cette invention concerne des polypeptides isolés qui sont exprimés de manière endogène à partir d'expansions de répétitions nucléotidiques. Dans certains cas, les répétitions polypeptidiques comprennent au moins cinq répétitions contiguës d'un même acide aminé. Dans d'autres, les répétitions comprennent au moins six acides aminés contigus d'une séquence à répétition du type tétra- ou penta-acide aminé.

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