C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2274011
The invention concerns in particular the human flavin-containing monooxygenase 2 (hFMO2), and another human enzyme of the FMO, hFMOx family, their nucleotide and polypeptide sequences. The invention also concerns vectors for cloning and/or expression containing said nucleotide sequences and cells transformed by these vectors and method for preparing said polypeptides. The invention further concerns methods for selecting compounds and of diagnosing predisposition to pathologies and/or deficiencies related to FMO's and pharmaceutical compositions containing said compounds for treating and/or preventing these pathologies.
La présente invention concerne notamment la flavine mono-oxygénase 2 humaine (hFMO2), ainsi qu'une autre enzyme humaine de la famille FMO, hFMOx, leurs séquences nucléotiques et polypeptidiques. La présente invention concerne également des vecteurs de clonage et/ou d'expression contenant lesdites séquences nucléotidiques et des cellules transformées par ces vecteurs ainsi que des méthodes de préparation desdits polypeptides. L'invention comprend aussi des méthodes de sélection de composés et de diagnostic de prédisposition à des pathologies et/ou des déficiences liées aux FMOs ainsi que des compositions pharmaceutiques comportant lesdits composés destinés au traitement et/ou à la prévention de ces pathologies.
Bach Jean-Francois
Blumenfeld Marta
Garchon Henri-Jean
Tchoumakov Ilia
Genset S.a.
Institut National de La Sante Et de La Recherche Medicale (inser
Serono Genetics Institute S.a.
Sim & Mcburney
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