Nucleotide sequence encoding artemisinic aldehyde double...

Details Nucleotide sequence encoding artemisinic aldehyde double... Nucleotide sequence encoding artemisinic aldehyde double...

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A01H 1/04 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12P 7/24 (2006.01) C12P 7/40 (2006.01) C12P 17/08 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2706424

An isolated nucleic acid molecule cloned from Artemisia annua encodes an artemisinic aldehyde double bond reductase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to (11R)-dihydroartemisinic aldehyde. The nucleic acid molecule, and the enzyme encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde and/or dihydroartemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the antimalarial compound artemisinin.

L'invention concerne une molécule d'acide nucléique isolée clonée à partir d'Artemisia annua codant pour une réductase de double liaison d'aldéhyde artémisinique. La réductase de double liaison d'aldéhyde artémisinique assure la réduction enzymatique de l'aldéhyde artémisinique en aldéhyde (11R)-dihydroartémisinique. La molécule d'acide nucléique, et l'enzyme codée par celle-ci, peuvent être utilisées dans des procédés pour produire de l'aldéhyde dihydroartémisinique et/ou de l'acide dihydroartémisinique dans une cellule hôte. L'acide dihydroartémisinique est un précurseur tardif du composé antipaludique artémisine.

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