Nucleotide sequence encoding carbamoyl phosphate synthetase ii

Details Nucleotide sequence encoding carbamoyl phosphate synthetase ii Nucleotide sequence encoding carbamoyl phosphate synthetase ii

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2150572

The present invention provides a nucleotide sequence encoding carbamoyl phosphate synthetase II of plasmodium falciparum. Carbarnoyl phosphate synthetase II catalyses the first committed and rate-limiting step in the de novo pyrimidine biosynthetic pathway. P. falciparum relies exclusively on pyrimidine synthesis de novo because of its inability to salvage pyrimidine. Mature human red blood cells, however, have no recognised requirement for pyrimidine nucleotide. Accordingly, this enzyme represents a prime chemotherapeutic locus. The present invention relates to the use of the sequence encoding carbamoyl phosphate synthetase II in the recombinant production of carbamoyl phosphate synthetase II and to antisense molecules, ribozymes and other gene inactivation agents designed from this sequence.

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