C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 9/48 (2006.01) C12N 15/57 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2553661
The present invention is directed to the assessment of transmissible spongiform encephalopathy (TSE) using a sample from a living individual. The assessment is based on the use of an RNA marker molecule in a sample of whole blood. The RNA encodes a hypothetical cystein protease. The invention is further directed to the detection of the marker molecule by means of real-time PCR. The invention provides the use of the nucleotide sequence as a marker in the assessment of TSE, a method for assessing bovine spongiform encephalopathy (BSE) in a bovine as well as kits to practice the invention.
Eberle Walter
Knoll Michael
Seitz Christoph
Borden Ladner Gervais Llp
F. Hoffmann-Laroche Ag
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