C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A01H 1/04 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12N 9/88 (2006.01) C12N 15/29 (2006.01) C12N 15/60 (2006.01) C12P 7/24 (2006.01) C12P 7/40 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2648135
Isolated nucleic acid molecules cloned from Artemisia annua encode artemisinic aldehyde double bond reductase and artemisinic/dihydroartemisinic aldehyde dehydrogenase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to dihydroartemisinic aldehyde. Artemisinic/dihydroartemisinic aldehyde dehydrogenase enzymatically oxidizes dihydroartemisinic aldehyde to dihydroartemisinic acid and artemisinic aldehyde to artemisinic acid. The nucleic acid molecules, and the enzymes encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde, dihydroartemisinic acid or artemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the antimalarial compound artemisinin.
Molécules d'acides nucléiques isolées clonées à partir d'Artemisia annua codant la réductase double liaison aldéhyde artémisinique et la déshydrogénase aldéhyde artémisinique/dihydroartémisinique. La réductase double liaison aldéhyde artémisinique assure la réduction enzymatique d'aldéhyde artémisinique en aldéhyde dihydroartémisinique. La déshydrogénase aldéhyde artémisinique/dihydroartémisinique assure l'oxydation enzymatique d'aldéhyde dihydroartémisinique en acide dihydroartémisinique et d'aldéhyde artéminisique en acide artémisinique. Les molécules d'acides nucléiques et les enzymes codées par elles sont utilisables dans des procédés d'élaboration d'aldéhyde dihydroartémisinique, d'acide dihydroartémisinique ou d'acide artémisinique dans une cellule hôte. L'acide dihydroartémisinique est un précurseur tardif de l'artémisinine de composé antipaludique.
Covello Patrick S.
Polichuk Devin R.
Reed Darwin W.
Teoh Keat (thomas) H.
Eckenswiller Laura Catherine
National Research Council Of Canada
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