Nucleotide sequences involved in increasing or decreasing...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408051

The present invention relates to nucleotide sequences which are involved in increasing or decreasing mammalian ovulation rate. In particular, it concerns mutations in a gene which is involved in increasing the ovulation rate in heterozygous female mammals; these mutations cause sterility in homozygous female mammals. Knowledge of the mutated gene sequence can be applied to a test for identifying heterozygous of homozygous female and male mammals carrying the mutated gene, to increase or decrease the ovulation rate of female mammals, or to induce sterility or reduced fertility in female mammals.

La présente invention concerne des séquences nucléotidiques associées à l'augmentation ou à la réduction du taux d'ovulation mammalien. L'invention concerne en particulier les nouvelles mutations d'un gène associé à l'augmentation du taux d'ovulation chez les mammifères femelles hétérozygotes. Ces mutations induisent une stérilité chez les mammifères femelles homozygotes. La connaissance de la séquence génique mutée peut s'appliquer à un essai servant à identifier des mammifères femelles et mâles hétérozygotes ou homozygotes porteurs du gène muté. Cette connaissance de la fonction biologique du gène et ses mutations peut également être utilisée pour augmenter ou réduire le taux d'ovulation des mammifères femelles, ou pour induire la stérilité ou une fertilité réduite chez les mammifères femelles.

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