Nucleotide sequences of avian herpes viruses

Details Nucleotide sequences of avian herpes viruses Nucleotide sequences of avian herpes viruses

C - Chemistry, Metallurgy

12

N

167/100, 530/13,

C12N 15/38 (2006.01) A61K 39/245 (2006.01) A61K 39/255 (2006.01) C07K 14/03 (2006.01) C07K 14/055 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1341307

Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.

611209

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