Nucleotide sequences, proteins, drugs and diagnostic agents...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2240449

A nucleotide sequence corresponding to a gene comprising (a) one of sequences SEQ ID 1 to 11, or an equivalent gene which comprises (b) a sequence hybridisable with one of the sequences of (a), (c) a sequence at least 80 % homologous with (a) or (b), or (d) a sequence coding for a protein encoded by a gene according to (a), (b) or (c), or for an equivalent protein, and the use thereof, in particular for controlling cancer as well as for therapeutic follow-up. These genes are in the TSAP (tumor suppressor activated pathway) group, designated TSAP 1 to TSAP 8 and TSAP 3 human (or HUMSIAH) and in TSIP (tumor suppressor inhibited pathway) group, designated TSIP 1 and TSIP 2, both types of genes corresponding to sequences activated or inhibited, respectively, during cellular apoptosis, particularly that induced by p53.

La présente invention concerne une séquence nucléotidique correspondant à un gène comportant: (a) une séquence selon l'une des IND. SEQ 1 à 11 ou un gène équivalent qui comporte: (b) une séquence s'hybridant avec l'une des séquences selon (a), (c) une séquence présentant au moins 80 % d'homologie avec (a) ou (b), ou (d) une séquence codant pour une protéine codée par une gène selon (a), (b) ou (c) ou pour un protéine équivalente, et leur application notamment dans la suppression du cancer ainsi que dans le suivi thérapeutique. Ces gènes regroupés en TSAP (tumor suppressor activated pathway) et dénommés TSAP 1 à TSAP 8 et TSAP 3 humain (ou HUMSIAH), et en TSIP (tumor suppressor inhibited pathway) et dénommés TSIP 1 et TSIP 2, ces deux types de gènes correspondant respectivement à des séquences induites ou inhibées lors de l'apoptose cellulaire, notamment celles induites par p53.

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