C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2239463
Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3' kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino acids, and that exhibit a bromodomain are described, as well as methods of using such proteins for medical applications, including diagnosis and treatment cell growth disorders.
L'invention concerne l'identification, la caractérisation, et l'expression de nucléotides codant une (des) protéine(s) associée(s) de phosphatidylinositol-3 kinase qui est (sont) liée(s) au domaine de SH2 intermédiaire sur la sous-unité régulatrice de PI3K, p85, au moyen des acides aminés C-terminaux de la (des)dites protéine(s) associée(s), et qui présente(nt) un domaine renfermant du brome. L'invention concerne également des procédés d'utilisation de telles protéines dans des applications médicales, notamment le diagnostic et le traitement des anomalies de croissance cellulaire.
Fetherstonhaugh & Co.
Onyx Pharmaceuticals Inc.
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