C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 39/12 (2006.01) A61K 39/29 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C12N 15/51 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2174652
Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a protein of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
Vecteur nucléotidique comprenant au moins un gène ou un ADN complémentaire codant pour au moins une partie d'une protéine d'un virus, et un promoteur permettant l'expression de ce gène dans des cellules musculaires. Le gène peut être le gène S du virus de l'hépatite B. Une préparation vaccinale contenant cet ADN nu est injectée à l'hôte préalablement prétraité par une substance capable d'induire une nécrose coagulatrice des fibres musculaires.
Davis Heather Lynn
Michel Marie-Louise
Whalen Robert Gerald
Institut National de La Sante Et de La Recherche Medicale
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur
Robic
Universite D'ottawa - University Of Ottawa
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