Nucleotide vector, composition containing such vector and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 39/12 (2006.01) A61K 39/29 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C12N 15/51 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2174652

Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a protein of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.

Vecteur nucléotidique comprenant au moins un gène ou un ADN complémentaire codant pour au moins une partie d'une protéine d'un virus, et un promoteur permettant l'expression de ce gène dans des cellules musculaires. Le gène peut être le gène S du virus de l'hépatite B. Une préparation vaccinale contenant cet ADN nu est injectée à l'hôte préalablement prétraité par une substance capable d'induire une nécrose coagulatrice des fibres musculaires.

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