Numb protein expression inhibitors by musashi

Details Numb protein expression inhibitors by musashi Numb protein expression inhibitors by musashi

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2418088

Numb protein expression inhibitors, Notch information transfer activity enhancers and nerve stem cell proliferation activity enhancers which comprise as the active ingredient a Musashi protein, polypeptides having an amino acid sequence derived from the amino acid sequence of the Musashi protein by substitution, deletion, addition or insertion of one or more amino acids or genes encoding these polypeptides. Thus, novel functions of the Musashi protein have been clarified. Namely, the Musashi protein inhibits the expression of the Numb protein capable of controlling neuron differentiation and enhances the activity of the Notch information transfer system, which makes it usable as remedies for various central nerve diseases.

Inhibiteur de l'expression de la protéine Numb, amplificateurs de l'activité de transfert d'informations de Notch et amplificateur de l'activité de prolifération des cellules souches nerveuses comprenant en tant qu'ingrédient actif une protéine musashi, polypeptides dont une séquence aminoacide est dérivée de la séquence aminoacide de la protéine musashi par substitution, délétion, addition ou insertion d'un ou de plusieurs acides aminés ou de gènes codant ces polypeptides. On a pu ainsi découvrir de nouvelles fonctions de la protéine musashi. Elle inhibe notamment l'expression de la protéine Numb capable de contrôler la différenciation neuronale et amplifie l'activité du système de transfert de l'information de Notch, ce qui la rend utilisable pour des remèdes à différentes maladies du système nerveux central.

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