Nup98-hox fusions for expansion of hemopoietic stem cells

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) A61P 35/02 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2573176

Nucleic acid constructs encoding homeobox-nucleoporin fusions are disclosed, compositions comprising same, and methods which provide enhanced expansion of stem cells. In particular, an isolated nucleic acid construct encoding a NUP98- HOX fusion is provided, which when introduced into hemopoietic stem cells provides enhanced expansion of these cells. Methods of expanding stem cells in vivoor ex vivoand methods of treatment using the stem cells are also described.

Cette invention concerne des constructions d'acides nucléiques codant des fusions d'homéoboîte-nucléoporine, des compositions renfermant ces constructions, ainsi que des procédés qui permettent d'obtenir une plus grande expansion de cellules souches. Cette invention concerne en particulier une construction d'acides nucléiques isolée codant une fusion NUP98-HOX qui, lorsqu'elle est introduite dans des cellules souches hématopoïétiques, entraîne une plus grande expansion de ces cellules. Cette invention concerne en outre des procédés d'expansion de cellules souches in vivo ou ex vivo ainsi que des méthodes de traitement faisant appel aux cellules souches.

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