C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 63/06 (2006.01) A61K 31/22 (2006.01) A61K 31/765 (2006.01) C07C 69/675 (2006.01) C07H 13/04 (2006.01) C08G 63/60 (2006.01)
Patent
CA 2527940
Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3- hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.
La présente invention se rapporte à de nouveaux composés et à de nouvelles compositions contenant des dérivés (R)-3-hydroxybutyrates. Ces composés et ces compositions peuvent être utilisés en tant que suppléments alimentaires pour améliorer les performances physiques et en tant qu'agents thérapeutiques pour améliorer les symptômes d'états pathologiques, notamment de troubles neurologiques, tels que la maladie d'Alzheimer et des troubles similaires. L'invention se rapporte à de nouveaux procédés de fabrication de dérivés (R)-3-hydroxybutyrates. Des procédés donnés en exemple mettent en oeuvre un solvant supercritique, tel que du dioxyde de carbone supercritique, et utilisent une réaction d'estérification ou de transestérification catalysée par une lipase pour produire ces dérivés (R)-3-hydroxybutyrates.
Clarke Kieran
King Michael T.
Veech Richard L.
Isis Innovation The Technology Transfer Company For The University Of O. Xford
Smart & Biggar
The Government Of The United States Of America As Represented By
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