Nutritional support of the immune system during anti-cancer...

A - Human Necessities – 61 – K

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A61K 35/74 (2006.01) A61K 31/20 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/40 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2737619

The present invention relates to methods and immunonutritional compositions for preventing the impairment of the immune function during anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently augment or enhance the immunocompetence of an immune cell and the immunogenecity of a tumor cell of a subject undergoing anti-cancer therapy-induced apoptosis and tumor-cell-enhanced immunogenicity such that the innate and adaptive immune functions and normal physiology of the immune cell are preserved, which, in turn, lead to (i) a better tolerance and increased efficacy to anti-cancer therapy; (ii) transient augmentation or enhancement of immunocompetence of the immune cell and immunogenecity of the tumor cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened by anti-cancer therapy.

La présente invention concerne des procédés et des compositions immunonutritionnelles pour prévenir laltération de la fonction immunitaire pendant une thérapie anticancéreuse, de manière à obtenir une meilleure efficacité du traitement. Plus particulièrement, la présente invention concerne des procédés et des compositions immunonutritionnelles qui peuvent augmenter ou renforcer temporairement limmunocompétence dune cellule immunitaire et limmunogénicité dune cellule tumorale dun sujet subissant une apoptose induite par une thérapie anticancéreuse et une immunogénicité augmentée de la cellule tumorale de sorte que les fonctions immunitaires innées et adaptatives et la physiologie normale de la cellule immunitaire soient conservées, ce qui, à son tour, conduit à (i) une meilleure tolérance et une efficacité augmentée de la thérapie anticancéreuse; (ii) une augmentation ou un renforcement transitoire de limmunocompétence de la cellule immunitaire et de limmunogénicité de la cellule tumorale; et (iii) une optimisation des effets de et une augmentation de limmunocompétence de la cellule immunitaire affaiblie par la thérapie anticancéreuse.

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