Nutritional support to prevent or moderate bone marrow...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/74 (2006.01) A61K 31/20 (2006.01) A61K 31/7088 (2006.01) A61K 35/20 (2006.01) A61K 38/00 (2006.01) A61K 38/40 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2736747

The present invention relates to methods and immunonutritional compositions for preventing the impairment of the immune function during anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject undergoing anti-cancer therapy-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to anti-cancer therapy; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened by anti-cancer therapy.

La présente invention concerne des procédés et des compositions immunonutritionnelles pour prévenir laltération de la fonction immunitaire pendant une thérapie anticancéreuse, de manière à obtenir une meilleure efficacité du traitement. Plus particulièrement, la présente invention concerne des procédés et des compositions immunonutritionnelles qui peuvent prévenir ou modérer de manière transitoire la paralysie de la moelle osseuse ou la neutropénie dun sujet subissant une apoptose ou une nécrose ou un autre dommage cellulaire induit par une thérapie anticancéreuse de sorte que les fonctions immunitaires innées et adaptatives et la physiologie normale de la moelle osseuse soient conservées, au moins en partie, ce qui, à son tour, conduit à (i) une meilleure tolérance et une efficacité augmentée de la thérapie anticancéreuse; (ii) une augmentation ou un renforcement transitoire de limmunocompétence de la cellule immunitaire; et (iii) une optimisation des effets de et une augmentation de limmunocompétence de la cellule immunitaire affaiblie par la thérapie anticancéreuse.

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