Ny-eso-1 peptide derivatives, and uses thereof

Details Ny-eso-1 peptide derivatives, and uses thereof Ny-eso-1 peptide derivatives, and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/08 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C12Q 1/04 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2390659

The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.

L'invention concerne des variants peptidiques qui se lient à des molécules du HLA, entraînant la lyse de cellules par l'intermédiaire de lignées de lymphocytes T cytolytiques. Les variants sont obtenus à partir de peptides de NY-ESO-1. Les peptides peuvent être incorporés dans des tétramères immunitaires qui sont utiles comme élutriateurs.

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