O-2-isocephem antibacterial agents and processes and...

Details O-2-isocephem antibacterial agents and processes and... O-2-isocephem antibacterial agents and processes and...

C - Chemistry, Metallurgy

07

D

260/244.7

C07D 498/04 (2006.01) C07D 205/085 (2006.01) C07D 257/04 (2006.01) C07D 317/30 (2006.01)

Patent

CA 1109873

ANTIBACTERIAL AGENT ABSTRACT OF THE DISCLOSURE The present invention provides for the stereoselective total synthesis of certain novel substituted .DELTA.2,3-1,4-morpholine- 2-carboxylic acids possessing a fused .beta.-Iactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula Image wherein Q is hydrogen, alkyl, aralkyl or -CH2COOZ where Z is hydrogen or the residue of an ester group and X is azido, amino or acylamino. When X is acyl- amino, these acids (and their pharmaceutically accept- able salts and physiologically hydrolyzed esters) are potent antibacterial agents. This divisional is directed to intermediate products used in the above preparation.

364190

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