O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process...

Details O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process... O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process...

C - Chemistry, Metallurgy

07

D

260/544.3, 260/3

C07D 295/14 (2006.01) C07C 259/14 (2006.01) C07D 213/78 (2006.01) C07D 217/04 (2006.01) C07D 295/088 (2006.01)

Patent

CA 1077506

ABSTRACT OF THE DISCLOSURE This invention relates to compounds of the general formula I and pharmaceutically acceptable salts thereof Image (I) wherein R2 hydrogen or alkyl having one to five carbon atoms; R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl; or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring; R4 is cycloalkyl, aromatic or heteroaromatic group, optionally substituted with one or more halogens, alkoxy or alkyl and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl; R5 is hydrogen or alkyl having one to four carbon atom cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms; R6 is hydrogen, alkyl having one to four carbon atoms or phenyl; m=0, 1 or 2; n = 0, 1 or 2. It also relates to a process for the preparation of these compounds. The compounds of formula I and their pharmaceutically acceptable salts are useful in treating diabetic angiopathy in mammals and in some instances are useful as hypotensive agents.

285529

Affiliated with

Also associated with

Rating

O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-180899