O-acylated derivatives of 1,5-dideoxy-1, 5-imino-d-glucitol

Details O-acylated derivatives of 1,5-dideoxy-1, 5-imino-d-glucitol O-acylated derivatives of 1,5-dideoxy-1, 5-imino-d-glucitol

C - Chemistry, Metallurgy

07

D

167/228, 260/276

C07D 211/46 (2006.01) A61K 31/445 (2006.01) C07D 401/06 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2002106

O-acylated derivatives of 1,5-dideoxy-1,5-imino-D-glucitol and their N-alkyl, N-acyl and N-aryl derivatives in which from one to four of the free hydroxyl groups are acylated with acyl groups having from one to eight carbon atoms and in which the N-alkyl and N-acyl substituents contain from four to fourteen carbon atoms and the N-aryl substituents contain from seven to fourteen carbon atoms are disclosed, provided that when N-aryl is benzyloxycarbonyl, the O-acyl groups contain four to eight carbon atoms. These compounds have use as antiviral agents and as inhibitors of glycosidase enzymes.

On divulgue des dérivés O-acylés du 1,5-didésoxy-1,5-imino-D-glucitol et de leurs dérivés N-alkylés, N-acylés et N-arylés dans lesquels de un à quatre groupements libres hydroxyles sont acylés à l'aide de groupements acyles comportant de un à huit atomes de carbone et dans lesquels les substituants N-alkyles et N-alcyles contiennent de quatre à quatorze atomes de carbones, et les substituants N-aryles contiennent de sept à quatorze atomes de carbone, sous réserve que les groupements O-acyles contiennent de quatre à huit atomes de carbone quand le groupement N-aryle est un benzyloxycarbonyle,. Ces composés sont utilisés comme agents antiviraux et comme inhibiteurs des glycosidases.

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