O-alkylated oximes

Details O-alkylated oximes O-alkylated oximes

C - Chemistry, Metallurgy

07

D

260/278, 260/266

C07D 211/28 (2006.01) C07D 209/14 (2006.01) C07D 211/14 (2006.01) C07D 213/53 (2006.01) C07D 213/80 (2006.01) C07D 295/088 (2006.01) C07D 295/12 (2006.01) C07D 303/12 (2006.01) C07D 333/22 (2006.01) C07D 403/12 (2006.01)

Patent

CA 1105019

A b s t r a c t Compounds of general formula Image (I) (wherein R1 represents a) a mono- or binuclear aryl group having from 6 to 10 carbon atoms, optionally substituted by from 1 to 3 alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen, phenyl, carboxyl, cyano, nitro and/or hydroxy groups, or b) a 5- or 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and the ring is optionally anellated to a benzene mucleus; R2 represents a hydrogen atom, or an alkyl group having up to 3 carbon atoms, a phenyl group or a cycloalkyl group having up to 6 carbon atoms in the ring and optional- ly bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents a hydrogen atom, or a hydroxy or acyloxy group; R4 and R5, which may be the same or different, each represents a hydrogen or halogen atom, or an alkyl or halogenoalkyl group each having up to 3 carbon atoms, or a nitro group; and X represents a nitrogen atom or a methine group) and physlologically acccptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing said compounds. These compouds find use in compositions for lowering blood cholesterol and triglyceride levels.

293840

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