O-anisamide derivatives

Details O-anisamide derivatives O-anisamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/60 (2006.01) A61K 31/166 (2006.01) A61K 31/192 (2006.01) A61K 31/235 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07C 317/46 (2006.01) C07C 323/60 (2006.01)

Patent

CA 2385083

The invention provides o-anisamide derivatives and their addition salts effective for the prevention and/or therapy of metabolic diseases such as hyperlipidemia and diabetes, in which peroxisome proliferator-activated receptor (PPAR) being intranuclear receptor, in particular, human PPAR participates, as agonistic drugs thereon, and processes for preparing them. The invention relates to o-anisamide derivatives represented by a general formula (1) (See formula I) [wherein R denotes a carboxyl group, carboxymethyl group or CH2CHXCOY (here X denotes a mercapto group or S(O)nMe (n =0, 1 or 2) and Y denotes an amino group or hydroxyl group)], their medicinally acceptable salts, their hydrates, and processes for preparing them.

L'invention concerne des dérivés d'o-anisamide servant d'agonistes du récepteur activé de la prolifération des peroxisomes (PPAR), en particulier des agonistes humains de PPAR, lesquels sont efficaces dans la prévention et/ou le traitement de maladies métaboliques auxquelles ils participent (hyperlipémie, diabète, etc.), leurs sels d'addition d'acide et un procédé pour leur production. L'invention concerne notamment des dérivés d'o-anisamide représentés par la formule générale (1), leurs sels acceptables sur le plan pharmaceutique et leurs hydrates, formule dans laquelle R représente carboxy, carboxyméthyle, CH2CHXCOY (où X représente mercapto ou S(O)nMe où n représente 0, 1 ou 2, et Y représente amino ou hydroxy).

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