C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/203 (2006.01) A61K 31/7034 (2006.01) A61P 7/12 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2404373
Formula (I) wherein Y is formula (a) or heteroaryl; A is -O(CH2)m, S, - NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2; and R1 to R6 are as defined herein. A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with one, two or more other antidiabetic agents, and/or one, two or more hypolipidemic agents.
Formule (I) dans laquelle Y est la formule (a) ou hétéroaryle; A est O(CH2)m, S, -NH(CH2)m, ou (CH2)n dans laquelle n est 0-3 est m est 0-2; et R1 à R6 sont définis dans l'invention. L'invention concerne aussi un procédé pour traiter le diabète et les maladies y liées en utilisant une quantité inhibitrice de SGLT2 du composé indiqué ci-dessus ou en combinaison avec un, deux ou plusieurs agents antidiabétiques et/ou un, deux ou plusieurs agents hypolipidémiques.
Sher Philip M.
Washburn William N.
Wu Gang
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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