O-carbamoyl-phenylalaninol having substituent at benzene...

Details O-carbamoyl-phenylalaninol having substituent at benzene... O-carbamoyl-phenylalaninol having substituent at benzene...

C - Chemistry, Metallurgy

07

C

C07C 271/12 (2006.01) C07C 269/06 (2006.01) C07C 323/32 (2006.01)

Patent

CA 2217771

O-carbamoyl-phenylalaninol having substituent at benzene ring, represented by general formula (I), and pharmaceutically useful salts thereof, which are useful for the prophylaxis and treatment of CNS disorder including depression and anxiety, are disclosed: wherein R is lower alkyl containing 1 to 8 carbon atoms; halogen such as F, Cl and I; alkoxy containing 1 to 3 carbon atoms; thioalkoxy containing 1 to 3 carbon atoms; nitro, hydroxy, or trifluorocarbon; and x is an integer of 1 to 3, with a proviso that R is the same or different when x is 2 or 3.

Cette invention concerne un O-carbamoylphenylalaninol ayant un substituant au niveau du cycle benzènique et correspondant à la formule développée (I), ainsi que ses sels utiles sur le plan pharmaceutique, lesquels sont utiles dans la prophylaxie et les traitements de troubles du système nerveux central comprenant les dépressions et l'anxiété. Dans ladite formule (I), R représente alkyle inférieur comportant de 1 à 8 atomes de carbone, halogène tel que F, Cl et I, alcoxy comportant de 1 à 3 atomes de carbone, thioalcoxy comportant de 1 à 3 atomes de carbone, nitro, hydroxy et trifluorocarbone, et x est un nombre entier allant de 1 à 3, étant entendu que R peut être identique ou différent lorsque x est égal à 2 ou 3.

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