O-desulfated heparin derivatives, methods of making and uses...

Details O-desulfated heparin derivatives, methods of making and uses... O-desulfated heparin derivatives, methods of making and uses...

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) A61K 31/727 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2189038

Compositions and methods of making selectively O-desulfated heparin compositions, preferably 6-O-desulfated heparin compositions wherein the methods permit regulating the degree of 6-O-desulfation. The compositions are useful for treating various diseases, including cancer, angiogenesis, shock, ischemia reperfusion injury, inflammation, and cardiovascular diseases including restenosis.

L'invention concerne des compositions ainsi que des procédés de production de compositions d'héparine sélectivement O-désulfatée, de préférence des compositions d'héparine 6-O-désulfatée, et des procédés permettant la régulation du degré de 6-O-désulfatation. Les compositions sont utiles dans le traitement de diverses maladies parmi lesquelles le cancer, l'angiogénèse, le choc hypovolémique, des lésions de reperfusion d'ischémie, des inflammations ainsi que des maladies cardiovasculaires y compris la resténose.

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