A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 31/715 (2006.01) A61K 38/17 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/00 (2006.01) C12N 9/10 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2646021
The present invention provides preventive approaches and treatments for an inflammatory bowel disorder (e.g., Crohn's disease or ulcerative colitis) or a gastrointestinal tumor (e.g., a colorectal cancer) comprising administering an O-glycan composition (e.g., mucins) to a subject, such as a human patient. In addition, the present invention also provides transgenic mice that fail to synthesize core 1-derived or core 3- derived O-glycans.
La présente invention concerne des approches préventives et des traitements pour des affections intestinales inflammatoires (par exemple, la maladie de Crohn ou une rectocolite hémorragique) ou une tumeur gastro-intestinale (par exemple, un cancer colorectal), qui consistent à administrer à un sujet, tel un patient humain, une composition d'O-glycane (par exemple, des mucines). En outre, la présente invention porte aussi sur des souris transgéniques qui ne synthétisent pas d'O-glycanes dérivées du noyau 1 ou 3.
Bcf Llp
Oklahoma Medical Research Foundation
LandOfFree
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