O-glycosylated igf-1

Details O-glycosylated igf-1 O-glycosylated igf-1

C - Chemistry, Metallurgy

12

N

530/9, 195/128.2

C12N 15/18 (2006.01) A61K 38/30 (2006.01) C07K 9/00 (2006.01) C07K 14/65 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1335802

The present application relates to an O-glycosylated human insulin-like growth factor (IGF-1). Insulin like growth factor displays insulin-like properties and also has a mediating effect on the action of growth hormone. Consequently, it is useful in the treatment of both diabetes and pituitary dwarfism. Unglycosylated IGF-1 must be administered in high doses as it tends to be sequestrated by specific binding proteins circulating in the bloodstream. High doses can lead to several undesirable side effects such as kidney complaints, obesity and a disturbed water balance. The present invention provides the preparation of O-glycosylated IGF-1 in yeast cells. IGF-1 glycosylated on the Thr29 amino acid has been demonstrated to have a reduced affinity to specific binding proteins and a more pronounced effect in lowering blood glucose levels.

608828

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