O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and...

Details O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and... O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and...

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2077331

TITLE OF THE INVENTION O-HETEROARYL, O-ALKYLHETEROARYL, O-ALKENYLHETEROARYL AND O-ALKYNYLHETEROARYL MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY ABSTRACT OF THE DISCLOSURE O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl- macrolides of the general structural Formula I: Image I -ii- have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

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