O-linked pyrimidin-4-amine-based compounds, compositions...

Details O-linked pyrimidin-4-amine-based compounds, compositions... O-linked pyrimidin-4-amine-based compounds, compositions...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2672673

A deoxycytidine kinase inhibitor of formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: L1 is a bond (i.e., the nitrogen is directly bound to A), -C(O)-, -SO2-, or -C(R4)2-; A is optionally substituted alkyl, aryl or heterocycle; R1 is hydrogen, halogen, -OH, -NH2, -NO2, -CN, -C(O)OR4, or optionally substituted alkyl; R2 is hydrogen, halogen, -OH, -NH2, -NO2, -CN, -C(O)OR4, or optionally substituted alkyl; each R3 is independently =O or optionally substituted lower alkyl; each R4 is independently hydrogen or lower alkyl; n is 1-3; and m is 0-3 if n is 1, m is 0-4 if n is 2, or m is 0-5 if n is 3, for the treatment of cancer.

L'invention concerne des composés à base de pyrimidine-4-amine à liaison O, des compositions pharmaceutiques les contenant et des procédés d'utilisation de ceux-ci. Des composés particuliers de l'invention sont représentés par la formule (I).

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