Ó-substituted polypeptides having therapeutic activity

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/04 (2006.01) A61K 31/27 (2006.01) A61K 38/04 (2006.01) C07C 271/22 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) C07K 5/09 (2006.01) C07K 5/097 (2006.01) C07K 5/107 (2006.01) C07K 5/113 (2006.01) C07K 7/06 (2006.01) C07K 14/66 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106764

2106764 9219254 PCTABS00017 The compounds of the invention are .alpha.-substituted mono-, di-, tri-, tetra-, and pentapeptides useful in treating obesity, anxiety, gastrointestinal ulcers, pain, stroke, and inflammation. They are also useful in blocking the reaction caused by withdrawal from drug or alcohol use and in reducing gastric acid secretion. They are further useful as agents in hypertension, heart failure, stroke, cognition, memory enhancement, spasticity, depression, diabetes, cancer, asthma, bladder dysfunction, psychosis, and arthritis and/or inflammatory pain. Pharmaceutical compositions, novel intermediates, and processes are also included.

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