C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/223, 167/246
C07D 317/48 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01)
Patent
CA 1242199
ABSTRACT The present invention provides pyruvic acid oximes of the general formula:- Image (I) wherein R is a hydrogen atom, a C3 - C8 cycloalkyl, C1 - C6 alkoxy, cinnamyloxy, phenylamino, phenyl-N- alkylamino or phenylthio radical or an aryl or aryloxy radical, the aryl moiety of which can be substituted one or more times by C1 - C6 alkyl, C1 - C6 alkoxy, halogen, hydroxyl, trifluoromethyl, amino, acetylamino, nitrile, nitro or methylenedioxy, A is a straight- chained or branched, saturated or unsaturated aliphatic hydrocarbon chain containing up to 10 carbon atoms, which can be substituted one or more times by halogen or hydroxyl,and R1 is a C1 - C8 alkyl radical, which can be substituted one or more times by halogen, hydroxyl, nitrile, phenyl or carboxyl, or is a nitrile or formyl group, with the proviso that R-A- is not a methyl, ethyl or benzyl radical; and the physio- logically acceptable salts, carboxylic acid esters and amides thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
386602
Heerdt Ruth
Hubner Manfred
Kuhnle Hans
Schmidt Felix H.
Wolff Hans P.
Boehringer Mannheim G.m.b.h.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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