O-sulfated bacterial polysaccharides

Details O-sulfated bacterial polysaccharides O-sulfated bacterial polysaccharides

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/125 (2006.01) A61K 31/715 (2006.01) A61P 31/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C07H 1/00 (2006.01) C08B 37/10 (2006.01)

Patent

CA 2279317

Process for the preparation of O-sulfated K4, K5 and K40 polysaccharides useful for the treatment of tumoral, HIV-1 and coagulation pathologies and in cosmetic preparations, wherein the K4, K5 or K40 polysaccharide in the form of sodium salt is suspended in an aprotic solvent and directly submitted to the reaction of O-sulfation with a pyridine- sulphur trioxide or trimethylamine-sulphur trioxide adduct or with chlorosulfonic acid.

Procédé de préparation de polysaccharides O-sulfatés K4, K5, K40 utiles pour traiter des pathologies tumorales, de coagulation et liées au VIH-1 et dans des préparations cosmétiques. Dans le procédé de préparation le polysaccharide K4, K5 OU k40 sous forme de sel de sodium est mis en suspension dans un solvant aprotique et soumis directement à la réaction d'ortho-sulfatation avec un produit d'addition au trioxyde de pyridine-soufre ou au trioxyde de triméthylamine-soufre ou avec de l'acide chlorosulfonique.

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