Ob fold domains

Details Ob fold domains Ob fold domains

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 14/195 (2006.01) C07K 17/00 (2006.01) C12N 7/01 (2006.01) C12N 15/11 (2006.01) C12N 15/31 (2006.01) C40B 30/04 (2006.01) C40B 40/02 (2006.01) C40B 50/00 (2006.01) C40B 50/06 (2006.01) G01N 33/68 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2653752

Provided herein are modified OB-fold domains having desired properties; methods of producing libraries of modified OB-fold domains; the libraries of modified OB-fold domains produced by such methods; methods for screening such libraries of modified OB-fold domains for desired biological activities; and the modified OB-fold domains identified from such libraries. Provided herein are modified OB-fold domains obtainable from Pyrobaculum aerophilum that exhibit modified binding interactions.

L'invention concerne des domaines de type OB fold modifiés ayant des propriétés désirées; des procédés de production de bibliothèques de domaines de type OB fold modifiés; les bibliothèques de domaines de type OB fold modifiés, obtenues par de tels procédés; des procédés pour cribler de telles bibliothèques de domaines de type OB fold modifiés pour des activités biologiques désirées; et les domaines de type OB fold modifiés identifiés à partir de telles bibliothèques. L'invention concerne des domaines de type OB fold modifiés pouvant être obtenus à partir de Pyrobaculum aerophilum qui présentent des interactions de liaison modifiées.

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