Ob-fold used as scaffold for engineering new specific binders

Details Ob-fold used as scaffold for engineering new specific binders Ob-fold used as scaffold for engineering new specific binders

C - Chemistry, Metallurgy

40

B

C40B 40/10 (2006.01) C07K 14/00 (2006.01) C07K 14/195 (2006.01) C12N 15/09 (2006.01) C40B 30/00 (2006.01) C40B 40/00 (2006.01) C40B 50/00 (2006.01) C40B 50/06 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2671553

The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.

L'invention concerne le domaine de l'ingénierie des protéines, et les moyens d'obtention de molécules stables susceptibles de se lier spécifiquement à une cible choisie dans une grande variété de familles de ligands. Plus précisément, l'invention concerne des procédés permettant d'obtenir une molécule se liant spécifiquement à une cible d'intérêt, par le biais d'une approche de mutation/sélection combinatoire avec une protéine à pli OB comme molécule de départ. Plus précisément, la cible d'intérêt peut être d'une formule de nature chimique différente, celle de la cible native de la protéine à pli OB utilisée comme molécule de départ.

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