Ob protein derivatives having prolonged half-life

Details Ob protein derivatives having prolonged half-life Ob protein derivatives having prolonged half-life

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) C07K 14/575 (2006.01) C07K 17/08 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238307

The present invention concerns long half-life derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reduction and for treating other physiological conditions by using the long half-life derivatives of OB.

Dérivés a demi-vie longue de la protéine OB de l'obésité. L'invention porte en particulier sur des chimères d'immunoglobuline-protéine OB et sur des dérivés polyéthylène-glycol (PEG)-OB qui présentent une demi-vie prolongée par rapport aux protéines OB natives correspondantes. L'invention porte en outre sur des méthodes de réduction de l'appétit et/ou d'amaigrissement et sur des méthodes de traitement d'autres états physiologiques à l'aide de dérivés à demi-vie prolongée de protéine OB.

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