Ob receptor isoforms and nucleic acids encoding them

Details Ob receptor isoforms and nucleic acids encoding them Ob receptor isoforms and nucleic acids encoding them

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/575 (2006.01) C07K 14/72 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2253832

The ob receptor has numerous isoforms resulting from alternative splicing; three novel isoforms, designated c', f, and g are disclosed. The nucleic acids encoding these isoforms are taught. Also part of the invention are vectors containing the nucleic acid encoding the receptors, host cells transformed with these genes, and assays which use the genes or protein isoforms.

Le récepteur du gène ob présente de nombreuses isoformes résultant d'un épissage différent, ces nouvelles isoformes, appelées c', f et g, sont décrites. Les acides nucléiques codant ces isoformes sont présentés. De même, une partie de l'invention a trait à des vecteurs contenant l'acide nucléique codant les récepteurs, des cellules hôtes transformées à l'aide de ces gènes ainsi que des dosages utilisant les gènes ou les isoformes protéiques.

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