Obligate heterodimer meganucleases and uses thereof

Details Obligate heterodimer meganucleases and uses thereof Obligate heterodimer meganucleases and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/55 (2006.01) C12N 15/66 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2677177

An obligate heterodimer meganuclease consisting of a first and a second monomer, deriving from two different homodimeric LAGLIDADG endonuclease monomers (parent monomers), and having at least one pair of mutations interesting corresponding residues of said parent monomers which make an inter- molecular interaction between the two monomers of each parent homodimeric LAGLIDADG endonuclease, a vector encoding said meganuclease, a cell, an animal or a plant modified by said vector and the use of said meganuclease and derived products for molecular biology, genome engineering and genome therapy.

L'invention porte sur une méganucléase hétérodimère obligatoire comportant un premier et un second monomère, provenant de deux monomères d'endonucléase LAGLIDADG homodimère différents (monomères parents) et possédant au moins une paire de mutations concernant des résidus correspondants desdits monomères parents qui forment une interaction intermoléculaire entre les deux monomères de chaque endonucléase LAGLIDADG homodimère parente, sur un vecteur codant pour ladite méganucléase, sur une cellule, un animal ou une plante modifiée par ledit vecteur et sur l'utilisation de ladite méganucléase et des produits dérivés pour la biologie moléculaire, le génie génomique et la thérapie génomique.

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