Obtaining free iodine in preparation of aqueous iodine...

A - Human Necessities – 61 – K

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A61K 49/04 (2006.01) C01B 7/13 (2006.01) C01B 9/02 (2006.01)

Patent

CA 2710105

This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to an improved method for the iodination reaction, a key step in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a method for producing free iodine in an aqueous solution of iodine chloride by adding minor amounts of potassium iodide.

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