C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/495 (2006.01) A61K 31/555 (2006.01) C07C 69/716 (2006.01) C07D 241/24 (2006.01) C07F 1/08 (2006.01) C07F 3/06 (2006.01) C07F 9/00 (2006.01) C07F 15/00 (2006.01)
Patent
CA 2133284
Disclosed herein are water-soluble octacarboxy substituted tetra(2,3- pyrazino)porphyrazines of the following formula: Image (I) wherein M is HH, Cu, VO, Co, Ni or Zn; and R is C2H5, n-C4H9, n-C6H13, n-C8H17 or ONa. The present invention discloses photoinactivators and more particularly a novel class of water soluble azaphathalocyanines (AzaPc's), functionalized on the macrocyle with carboxy substituents to yield octacarboxy substituted tetra(2,3- pyrazino)porphyrazines (TTPA's). The invention also relates to processes for their preparation and the use thereof for the photodynamic therapy of cancer and the inactivation of viruses or bacteria in stored blood products.
Galpern Maria G.
Kudrevich Svetlana
Van Lier Johannes E.
Goudreau Gage Dubuc
Universite de Sherbrooke
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