Octahydro-2h-pyrrolo (3,4,-g) quinolines

Details Octahydro-2h-pyrrolo (3,4,-g) quinolines Octahydro-2h-pyrrolo (3,4,-g) quinolines

C - Chemistry, Metallurgy

07

D

260/273.5

C07D 471/04 (2006.01)

Patent

CA 1145750

Abstract of the Disclosure Described herein are novel compounds of the formula Image IC wherein R1 is H or (C1-C3) alkyl-CO; R2 is H, benzyl or C1-C3 alkyl; and R3 is H, COO(C1-C3)alkyl, COOH, or CH2X1 wherein X1 is OH, Cl, OSO2(C1-C3)alkyl, OSO2to1yl, or OSO2phenyl; with the proviso that both R1 and R3 can not be H when R2 is C1-C3 alkyl; and their salts. These compounds are useful as intermediates in preparing octahydro-2H-pyrrolo [3,4-g] quinolines of the formula Image wherein R1 is H or C1-C3 alkyl; R2 ic C1-C3 alkyl or allyl; R3 is H or CH2X wherein X is CN, CONH2, SO2CH3, SCH3 or OCH3. The compounds of formula I are useful as dopamine agonists, and particularly as inhibitors of prolactin secretion and in treatment of Parkinsonism.

403807

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