Octahydro-oxazolo (4,5-g)quinolines

Details Octahydro-oxazolo (4,5-g)quinolines Octahydro-oxazolo (4,5-g)quinolines

C - Chemistry, Metallurgy

07

D

167/227, 260/273

C07D 498/04 (2006.01) A61K 31/41 (2006.01) C07D 215/20 (2006.01) C07D 215/38 (2006.01)

Patent

CA 1292742

ABSTRACT OF THE DISCLOSURE The present invention as disclosed provides trans- octahydro-oxazolo [4,5 g] quinolines of the formula I- Image wherein R is H, benzyl, C1-3 straight-chain alkyl or allyl and R1 is J. C1, Br, C1-3 alkyl, O-C1-3 alkyl, OH, NH2, NHC1-3 alkyl and wherein the 4a and 8a hydrogen atoms are in a trans relationship, individual enantioners thereof, and pharmaceutically acceptable salts thereof. These compounds are useful as dopamine D-2 agonists, and thus have utility as prolactin secretion inhibitors and in the treatment of Parkinson's disease, sexual dysfunction, anxiety or depression.

487985

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