Octahydro pyrazolo (3,4,-g) quinolines

Details Octahydro pyrazolo (3,4,-g) quinolines Octahydro pyrazolo (3,4,-g) quinolines

C - Chemistry, Metallurgy

07

D

260/283

C07D 215/00 (2006.01) C07D 217/00 (2006.01)

Patent

CA 1136629

X-4988 C Abstract of the Disclosure Octahydropyrazolo[3,4-g]quinolines, dopamine agonists, useful in treatment of Parkinsonism and in inhibiting secretion of prolactin, are described herein. These novel compounds are prepared by reacting a corresponding 7-dimethylaminomethylene-6- oxo-derivative with hydrazine hydrate. Also disclosed herein are intermediates of the formula Image XII wherein R is (C1-C3) alkyl, allyl or benzyl and Z' is (C1-C2) alkyl, benzyl, phenethyl or p-methoxybenzyl. These intermediates are prepared by a process which comprises subjecting a compound of general formula XI: Image XI wherein R and Z' are defined as before, and Z is (C1-C3) alkyl, (C2-C3) alkenyl, (C2-C3) alkynyl, (C5-C6) cycloalkyl, phenyl or methyl, methoxy or chloro-substituted phenyl; to hydrolysis to yield a 6-hydroxy-3-carboxylic acid, followed by reesterification with an alcohol in the presence of acid.

379595

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