Octahydro pyrazolo (3,4-g) quinolines

Details Octahydro pyrazolo (3,4-g) quinolines Octahydro pyrazolo (3,4-g) quinolines

C - Chemistry, Metallurgy

07

D

260/283

C07D 215/20 (2006.01)

Patent

CA 1133487

X-4988E Abstract of the Disclosure Octahydropyrazolo[3,4-g]quinolines, dopamine agonists, useful in treatment of Parkinsonism and in inhibiting secretion of prolactin, are described herein. These novel compounds are prepared by reacting a corresponding 7-dimethylaminomethylene-6- oxo-derivative with hydrazine hydrate. Also disclosed herein are intermediates of the formula XIV Image wherein R is (C1-C3) alkyl, allyl or benzyl and R1 is COOZ' wherein Z' is (C1-C2) alkyl, benzyl, phenethyl or p-methoxybenzyl. These intermediates are prepared by a process which comprises reacting a compound of the formula Image XIII wherein R and Z' are defined as before, with dimethylformamide dimethylacetal.

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