Octahydro-pyrrolo[3,4-c] derivatives and their use as...

Details Octahydro-pyrrolo[3,4-c] derivatives and their use as... Octahydro-pyrrolo[3,4-c] derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01)

Patent

CA 2569910

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).

Selon l'invention, les antagonistes des récepteurs de chimiokine, en particulier les composés 3,7-diazabicyclo[3.3.0]octane de formule (I), sont des antagonistes des récepteurs CCR5 de chimiokine qui sont utiles dans le traitement ou la prévention de l'infection au virus de l'immunodéficience humaine (VIH), ou dans le traitement du SIDA ou du syndrome apparenté au SIDA. L'invention concerne également des méthodes de traitement de maladies pouvant être atténuées au moyen d'antagonistes des CCR5. L'invention concerne encore des compositions pharmaceutiques et des méthodes d'utilisation desdits composés dans le traitement de ces maladies. L'invention concerne enfin des procédés de préparation des composés de formule (I).

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