Octahydroindolizinepropanoic acids and related compounds as...

Details Octahydroindolizinepropanoic acids and related compounds as... Octahydroindolizinepropanoic acids and related compounds as...

C - Chemistry, Metallurgy

07

D

167/231, 260/271

C07D 455/02 (2006.01) A61K 31/44 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1257268

Abstract Octahydro-5-oxoindolizine-6-propanoic acids and octahydro-6-oxopyrido[1,2-a]pyridine-7-propanoic acids, the decarboxy and related ester and perhydro derivatives thereof inhibit angiotensin I converting enzyme and are hypotensive agents. Hydrogenation of A58365 factors A and B, obtained by culturing Strepto- myces chromofuscus, provides these compounds.

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