Octahydronaphthalene derivatives and their preparation

Details Octahydronaphthalene derivatives and their preparation Octahydronaphthalene derivatives and their preparation

C - Chemistry, Metallurgy

07

C

260/357.3, 260/3

C07C 69/30 (2006.01) C07C 59/90 (2006.01) C07C 251/44 (2006.01) C07D 309/30 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1298845

ABSTRACT Compounds of formula (I): (I) Image [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R1 and R2 are the same or different and each represents an oxygen atom or a group of formula =N-OR3 (wherein R3 represents a hydrogen atom or a C1-C3 alkyl group)], the free hydroxy-carboxylic acids corresponding thereto and pharmaceutically acceptable salts and esters of said acids may be prepared by oxidising and, if necessary, oximating a corresponding ML-236A, ML-236B, MB-530A or MB-530B compound, and these compounds have valuable antihypercholesteraemic activity.

411825

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