Octahydronaphthalene oxime derivatives for cholesterol...

C - Chemistry – Metallurgy – 12 – P

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C12P 13/00 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 251/32 (2006.01) C07C 251/34 (2006.01) C07C 251/52 (2006.01) C07C 251/54 (2006.01) C07C 251/58 (2006.01) C07C 251/60 (2006.01) C07C 255/54 (2006.01) C07D 207/337 (2006.01) C07D 261/08 (2006.01) C07D 277/30 (2006.01) C07D 295/088 (2006.01) C07D 307/42 (2006.01) C07D 307/54 (2006.01) C07D 319/06 (2006.01) C07D 333/16 (2006.01) C07D 333/24 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12P 17/00 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2096281

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cycloalkyl or a heterocyclic group) have the ability to inhibit the biosynthesis of cholesterol, and can thus be used for the treatment and prophylaxis of diseases relating to high blood cholesterol levels. CA

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