Octahydrophenanthrene derivatives

Details Octahydrophenanthrene derivatives Octahydrophenanthrene derivatives

C - Chemistry, Metallurgy

07

C

C07C 215/44 (2006.01) A61K 31/135 (2006.01) A61K 31/22 (2006.01) A61K 31/44 (2006.01) C07C 215/42 (2006.01) C07C 215/52 (2006.01) C07C 215/70 (2006.01) C07C 217/60 (2006.01) C07C 217/74 (2006.01) C07C 219/24 (2006.01) C07D 213/63 (2006.01) C07D 213/64 (2006.01) C07D 307/92 (2006.01)

Patent

CA 2111138

Abstract Octahydrophenanthrene derivatives Compounds of the general formula Image I wherein R1 and R2 each individually signify hydrogen or lower alkyl optionally substituted by aryl or C3-6-cycloalkyl; R4 and R5 either both signify hydrogen or both signify halogen or one signifies hydrogen and the other signifies halogen, hydroxy, lower alkoxy, aryloxy or amino and R3 signifies hydrogen or, where no primary or secondary amino group(s) is/are present, alkanoyl, as well as pharmaceutically usable salts of compounds of formula 1 with acids have valuable pharmacodynamic properties as non- competitive NMDA antagonists and can accordingly be used as neuroprotectives. These compounds are novel with the exception of rac-cis- 4b-(2-amino-ethyl)-4b,5,6,7,8,8a.9,10-octahydro-phenanthren- 8a-ol.

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