C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/77 (2006.01) A61K 31/4402 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2545020
The present invention relates to compounds of the formula (I) their isomer, prodrugs of these compounds or isomers, or a pharmaceutically acceptable salts of these compounds, isomers or prodrugs; wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are defined as in the specification, to pharmaceutical compositions containing them and methods of using these compounds, their isomer, prodrugs of these compounds or isomers, or a pharmaceutically acceptable salts of these compounds, isomers or prodrugs to treat obesity, diabetes, anxiety, or inflammatory diseases or for modulating a process mediated by GR in mammals.
L'invention concerne des composés de la formule (I), leurs isomères, des promédicaments de ces composés ou isomères, ou bien un sel pharmaceutiquement acceptable de ces composés, isomères ou promédicaments, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, R¿9 ?et X étant tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques les contenant et des méthodes pour utiliser ces composés, leurs isomères, des promédicaments de ces composés ou isomères, ou bien un sel pharmaceutiquement acceptable de ces composés, isomères ou promédicaments pour traiter l'obésité, le diabète, l'anxiété, ou bien des maladies inflammatoires ou encore pour moduler un processus médié par le récepteur des glucocorticoïdes chez les mammifères.
Cheng Hengmiao
Kleinman Edward Fox
Robinson Ralph Pelton Jr.
Pfizer Products Inc.
Sim & Mcburney
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