Octahydropyrrolo [3, 4-c] pyrrole derivatives and their use...

Details Octahydropyrrolo [3, 4-c] pyrrole derivatives and their use... Octahydropyrrolo [3, 4-c] pyrrole derivatives and their use...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2662835

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) wherein R1-R3 and Ar are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).

Antagonistes du récepteur de chimiokine, notamment des composés de 3,7-diazabicyclo-[3.3.0]-octane de formule (I), dans laquelle R1-R3 et Ar sont tels que définis dans le présent document, lesdits composés étant des antagonistes des récepteurs de chimiokine CCR5, qui sont utiles pour le traitement ou la prévention d'une infection par le virus de l'immunodéficience humaine (VIH), ou pour le traitement du SIDA ou de l'ARC. L'invention concerne également des procédés de traitement de maladies qui sont soulagées par les antagonistes CCR5. L'invention concerne des compositions pharmaceutiques et des procédés d'utilisation des composés pour le traitement de ces maladies. L'invention concerne également des procédés de préparation de composés de formule (I).

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